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224 words Introduction: 597 words Discussion: 1331 words ABBREVIATIONS: AM251, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1Hpyrazole-3-carboxamide; CHX, cycloheximide; ERR, estrogen-related receptor; ERRE, ERR-responsive element; PGC-1, peroxisome proliferator-activated receptor γ coactivator-1; PMA, phorbol 12-myristate 13-acetate; rimonabant (SR141716A), 5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin1-yl)-1H-pyrazole-3-carboxamide; RT-PCR, real-time polymerase chain reaction; siRNA, small interfering RNA; SLV319 (Ibipinabant), 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydroN'-methyl-4-phenyl-1H-pyrazole-1-carboximidamide; XCT790, thiadiazoleacrylamide; ∆ψm, mitochondrial membrane potential; This article has not been copyedited and formatted. The final version may differ from this version. Molecular Pharmacology Fast Forward. Published on October 12, 2012 as DOI: 10.1124/mol.112.082651 at A PE T Jornals on M arch 0, 2017 m oharm .aspeurnals.org D ow nladed from